Substance P is the first neuroactive substance that is proposed as a neurotransmitter. As for the pharmacological properties of substance P, they were demonstrated to check exhibiting potent hypotensive properties that were not blocked by atropine. He was later identified as the first active neuropeptide and was proposed as a neurotransmitter. In the 70s the structure is now known to contain eleven amino acids, of which six corresponding to the C-terminus are essential for its biological activity was determined. Substance P (SP) is a neuropeptide of eleven amino acids, are much smaller than other neurotransmitters amounts, is synthesized in the cell body and transported along the axon to the terminals, it is synthesized as part of a prepropeptide ( preproteins or precursors) of higher molecular weight which then moves to the cisterns of the endoplasmic reticulum, where it is disintegrated to produce a proprotein. The proprotein is transported to the Golgi apparatus, where they may fac...
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