The polymerase chain reaction (PCR) and molecular hybridization were used for detecting and typing human papillomavirus (HPV) in 40 patients with clinical lesions as a control group and in 20 healthy subjects, biopsies on clinically normal oral mucosa. Amplification of HPV DNA was performed using specific oligonucleotide primers: MY09 and MY11 and for typing hybridization was used in plates comprising a mixture of probes of high, intermediate and low oncogenic risk, such as types 2, 4, 6, 11, 13, 16, 18 and 32. The results demonstrated the presence of HPV viral genome in 55 percent (22/40) of benign lesions of the mouth and 10 percent (2/20) in the control group. In oral benign lesions that were positive by PCR, we observed 90.9 percent (20/22) of the type HPV low risk and 9.1 percent (2/22) of HPV and low oncogenic risk lato. In the control group it was detected 5 percent (1/20) of low-risk HPV and 5 percent (1/20) of HPV high and low oncogenic risk.
Alzheimer's disease (AD) has become a growing problem in the medical, psychiatric, neurological, epidemiological, social and economic order, particularly in countries with a high life expectancy Alzheimer's dementia can be classified according to the age of onset in presenile or early onset, which appears before age 65 and senile or late onset, ie onset after age 65. It according to the presence or absence of a family history of the disease is classified into familial AD and sporadic AD, respectively. However, these classifications are not mutually exclusive. The development achieved by genetic has demonstrated the involvement of several chromosomes in the development of the disease. Chromosomes 1, 14 and 21 are associated with familial forms of start precoz. While late onset forms appear linked to chromosomes 12 and 19 In this paper we delved into the study of chromosome 21 and the amyloid beta protein , because there are many findings that relate to deposit excess am...
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