Substance P is the first neuroactive substance that is proposed as a neurotransmitter. As for the pharmacological properties of substance P, they were demonstrated to check exhibiting potent hypotensive properties that were not blocked by atropine. He was later identified as the first active neuropeptide and was proposed as a neurotransmitter. In the 70s the structure is now known to contain eleven amino acids, of which six corresponding to the C-terminus are essential for its biological activity was determined.
Substance P (SP) is a neuropeptide of eleven amino acids, are much smaller than other neurotransmitters amounts, is synthesized in the cell body and transported along the axon to the terminals, it is synthesized as part of a prepropeptide ( preproteins or precursors) of higher molecular weight which then moves to the cisterns of the endoplasmic reticulum, where it is disintegrated to produce a proprotein. The proprotein is transported to the Golgi apparatus, where they may face its first split. Finally is subjected to a limited proteolytic cleavage so that shorter and assembled in neurosecretory granules occurring peptides. It not recaptada or recycled by nerve terminals. It stimulates contraction of vascular and extravascular smooth muscle, causes intense salivation reinforcement.
Has shown the presence of substance P in the brain and other regions of the SNP (iris, skin, via nigroestrialtal, salivary glands) and in most of the areas of the CNS, with high concentrations in the hypothalamus and in the dorsal horn spinal cord, its concentration in the substantia nigra is the highest so far reported.
it has set the release of substance P related calcium-dependent stimulation and apparently is used as a neurotransmitter by nodes for sensory synapses. It is believed that substance P has a function of primary sensory excitatory neurotransmitter in the spinal cord and sympathetic ganglia. Endorphins, morphine inhibit release of substance P cuts trigeminal nucleus. Functions are substance P stimulate the contraction of vascular and extravascular smooth muscle, causing intense salivation reinforcement and other central actions. It has demonstrated its presence in gut, salivary glands and in most areas of the CNS, especially in substantia nigra and hypothalamus, and in the dorsal horn of the spinal cord.
Substance P (SP) is a neuropeptide of eleven amino acids, are much smaller than other neurotransmitters amounts, is synthesized in the cell body and transported along the axon to the terminals, it is synthesized as part of a prepropeptide ( preproteins or precursors) of higher molecular weight which then moves to the cisterns of the endoplasmic reticulum, where it is disintegrated to produce a proprotein. The proprotein is transported to the Golgi apparatus, where they may face its first split. Finally is subjected to a limited proteolytic cleavage so that shorter and assembled in neurosecretory granules occurring peptides. It not recaptada or recycled by nerve terminals. It stimulates contraction of vascular and extravascular smooth muscle, causes intense salivation reinforcement.
Has shown the presence of substance P in the brain and other regions of the SNP (iris, skin, via nigroestrialtal, salivary glands) and in most of the areas of the CNS, with high concentrations in the hypothalamus and in the dorsal horn spinal cord, its concentration in the substantia nigra is the highest so far reported.
it has set the release of substance P related calcium-dependent stimulation and apparently is used as a neurotransmitter by nodes for sensory synapses. It is believed that substance P has a function of primary sensory excitatory neurotransmitter in the spinal cord and sympathetic ganglia. Endorphins, morphine inhibit release of substance P cuts trigeminal nucleus. Functions are substance P stimulate the contraction of vascular and extravascular smooth muscle, causing intense salivation reinforcement and other central actions. It has demonstrated its presence in gut, salivary glands and in most areas of the CNS, especially in substantia nigra and hypothalamus, and in the dorsal horn of the spinal cord.
Comentarios