Tetrahydrocannabinol (THC), also known as delta-9-tetrahydrocannabinol, is the main psychoactive constituent of cannabis. What first they isolated in 1964 Raphael Mechoulam and Yechiel Gaoni, when pure, is a glassy solid at low temperatures, and becomes viscous and sticky when heated. THC is poorly soluble in water, but dissolves readily in most organic solvents, specifically lipids and alcohols.
As most pharmacologically active secondary metabolites of plants, it is believed that THC cannabis is involved in the defense mechanism of the plant, perhaps against herbivores, but now still unknown. THC also possesses high absorption properties UV-B (280-315 nm); it has been speculated that it could protect the plant from harmful UV radiation exposure.
Its pharmacological effects are the result of its relationship with cannabinol specific receptors located in the brain and throughout the body.
The pharmacological actions of THC partially result from their agonist activity at the cannabinoid CB1 receptor is located primarily in the central nervous system and the CB2 receptor, expressed mainly in cells inmune.system The psychoactive effects of THC are mediated primarily by its activation of G-protein coupled receptors CB1.It is generating a decrease in the concentrations of the cAMP second messenger molecule through inhibition of adenylyl cyclase.
THC has a mild to moderate analgesic effect and the effect of cannabis psicotrópiccan treat pain by altering transmitter release in the spinal ganglion of the spinal cord and the periaqueductal gray.
Other effects include relaxation, impaired visual senses, hearing, smell, fatigue and appetite stimulation. It has been shown that phytocannabinoids, especially THC and CBD, reduce permeability intestinal.Tiene antiemetic properties, and could also reduce aggression in certain individuals
As most pharmacologically active secondary metabolites of plants, it is believed that THC cannabis is involved in the defense mechanism of the plant, perhaps against herbivores, but now still unknown. THC also possesses high absorption properties UV-B (280-315 nm); it has been speculated that it could protect the plant from harmful UV radiation exposure.
Its pharmacological effects are the result of its relationship with cannabinol specific receptors located in the brain and throughout the body.
The pharmacological actions of THC partially result from their agonist activity at the cannabinoid CB1 receptor is located primarily in the central nervous system and the CB2 receptor, expressed mainly in cells inmune.system The psychoactive effects of THC are mediated primarily by its activation of G-protein coupled receptors CB1.It is generating a decrease in the concentrations of the cAMP second messenger molecule through inhibition of adenylyl cyclase.
THC has a mild to moderate analgesic effect and the effect of cannabis psicotrópiccan treat pain by altering transmitter release in the spinal ganglion of the spinal cord and the periaqueductal gray.
Other effects include relaxation, impaired visual senses, hearing, smell, fatigue and appetite stimulation. It has been shown that phytocannabinoids, especially THC and CBD, reduce permeability intestinal.Tiene antiemetic properties, and could also reduce aggression in certain individuals
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