Damiana Willd, Commonly Known as Damiana, is employed in traditional medicine as a stimulant, aphrodisiac, and diuretic. Its leaves and stems are used for flavoring and infusion. Damiana is Considered to be safe for medical use by the FDA. Have Pharmacological studies established the hypoglycemic, antiaromatase, prosexual, estrogenic, anti-bacterial, and antioxidant activity of T. diffusa. The aim of the present study was to Evaluate the possible cytotoxic effect of extracts and organic fractions of esta plant on five tumor cell lines (SiHa, C-33, Hep G2, MDA-MB-231, and T-47D) and regular human fibroblasts. The results show That the methanolic extract (ToM) greater activity on displayed MDA-MB-231 breast cancer cells (with an IC50 of 30.67 mg / mL) than on the other cancer cell lines. Four organic fractions of esta extract exhibited activity on This cancer cell line. In the most active fraction (F4), two active compounds Were isolated, arbutin,
and apigenin . This is the first report of a cytotoxic effect by T. diffusa on cancer cells. The IC50 values Suggest That the methanolic extract of T. diffusa has potential as an anticancer therapy.
Arbutin, hydroquinone derivative, is an active substance naturally found in the leaves of bearberry, also called "bearberry" (bearberry) or Arcthostaphylos uva-ursi. Very popular in Japan and Asia, this plant is used to whiten skin, reduce pregnancy masks, melasma, brands associated with sunburns or to regulate melanogenesis.
In topical application, arbutin is considered a skin depigmenting agent of .
Arbutin is a hydroquinone derivative known for its depigmenting properties. Hydroquinone is the depigmentation of reference used in dermatology (by prescription only) in the form of master preparations with concentrations of the order of 2 to 5%.
Arbutin is better tolerated than hydroquinone and can be used in cosmetics.
This active effectively inhibits tyrosinase activity and therefore melanin production
Accelerates the decomposition and removal of melanin. Thanks to structural similarities with tyrosinase substrates, arbutin act following a competition mechanism, linking to the active sites of the enzyme
In addition, arbutin has the ability to inhibit DHICA Polymerase (5,6-dihydroxy-indole-2-carboxylic acid) product resulting from the oxidation of tyrosine by tyrosinase
and apigenin . This is the first report of a cytotoxic effect by T. diffusa on cancer cells. The IC50 values Suggest That the methanolic extract of T. diffusa has potential as an anticancer therapy.
Arbutin, hydroquinone derivative, is an active substance naturally found in the leaves of bearberry, also called "bearberry" (bearberry) or Arcthostaphylos uva-ursi. Very popular in Japan and Asia, this plant is used to whiten skin, reduce pregnancy masks, melasma, brands associated with sunburns or to regulate melanogenesis.
In topical application, arbutin is considered a skin depigmenting agent of .
Arbutin is a hydroquinone derivative known for its depigmenting properties. Hydroquinone is the depigmentation of reference used in dermatology (by prescription only) in the form of master preparations with concentrations of the order of 2 to 5%.
Arbutin is better tolerated than hydroquinone and can be used in cosmetics.
This active effectively inhibits tyrosinase activity and therefore melanin production
Accelerates the decomposition and removal of melanin. Thanks to structural similarities with tyrosinase substrates, arbutin act following a competition mechanism, linking to the active sites of the enzyme
In addition, arbutin has the ability to inhibit DHICA Polymerase (5,6-dihydroxy-indole-2-carboxylic acid) product resulting from the oxidation of tyrosine by tyrosinase
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