Ir al contenido principal

tau protein

Alzheimer's disease (AD) has become a growing problem in the medical, psychiatric, neurological, epidemiological, social and economic order, particularly in countries with a high life expectancy
Alzheimer's dementia can be classified according to the age of onset in presenile or early onset, which appears before age 65 and senile or late onset, ie onset after age 65. It according to the presence or absence of a family history of the disease is classified into familial AD and sporadic AD, respectively. However, these classifications are not mutually exclusive.
The development achieved by genetic has demonstrated the involvement of several chromosomes in the development of the disease. Chromosomes 1, 14 and 21 are associated with familial forms of start precoz. While late onset forms appear linked to chromosomes 12 and 19
In this paper we delved into the study of chromosome 21 and the amyloid beta protein, because there are many findings that relate to deposit excess amounts of this protein among the leading causes of disease. Furthermore, aspects of chromosome 17 and treated Tau protein, because the latter is the main constituent of neurofibrillary tangles, whose number is directly related to the severity of dementia. However it is important to note that these are not the only issues involved in the pathogenesis of the disease.
The first incident involving chromosome 21 AD broke that individuals with Down syndrome (trisomy 21) invariably developed clinicopathological features of the disease, if they lived above the 30 years. Subsequent studies of senile plaques, first observable event in AD pathology, showed that its main constituent was the beta amyloid (SSA).

Amyloid plaques and neurofibrillary tangles are neuropathological hallmark lesions of Alzheimer disease (AD) The most common form of neurodegenerative disorder. Neurofibrillary tangles are intracellular hyperphosphorylated Tau inclusions FORMED of Plaques are extracellular inclusions mainly formed of a small peptide called amyloid-β (Aß). Clinically, AD is Characterized by profound memory loss and cognitive dysfunction. Growing evidence is converging on soluble Aß as a mediator of early cognitive decline in AD. , Although the Molecular Mechanisms underlying Aß-induced cognitive decline remain elusive, soluble Aß oligomers shown to alter Have Been signal transduction pathways are key for That learning and memory, suggesting That Alterations in May Such pathways underlie the onset of cognitive decline in AD

Comentarios

Entradas populares de este blog

ley de Monro Kellie

El cráneo contiene tres elementos : tejido nervioso, sangre y liquido cefalorraquídeo, cuyo volumen total siempre debe ser constante. The skull contains three elements: nervous tissue , blood and cerebrospinal fluid , the total volume should always be constant. Череп содержит три элемента: нервной ткани , крови и цереброспинальной жидкости , общий объем должен быть всегда постоянным. 頭骨包含三個元素:神經組織,血液和腦脊髓液,庫約общая總是Дебесерконстант量。

Cytokines

Cytokines are a group of proteins that regulate interactions of immune cells. His immunoregulatory function is key in immune response, inflammation.Cytokines are a group of small molecular weight proteins synthesized by many cells particularly immune cells.ts function is immunoregulatory be fundamental in communication and interactions that establish the immune system cells with each other and with other cells . Cytokines direct the innate immune response and specific immune response and are involved in inflammation and hematopoiesis. activated macrophages , eosinophils , neutrophils and NK cells , induce the production of reactive oxygen species and nitrogen and macrophages involved in hematopoietic processes. Involved in such important processes as inflammation, regulation of MHC expression (Major Histocompatibility Complex) class I and class II immunosuppressive responses, regulation of isotype switching of immunoglobulins ,

Shatavari root

The powdered dried root of Asparagus racemosus ( Shatavari ) is used in Ayurveda for dyspepsia ( amlapitta or acid regurgitation ) and to increase milk secretion in a lactating woman. A mixture 'Lactare', containing Asparagus racemosus as its major component, has been reported to cause significant rise in  prolactin levels. The alcoholic extract of Asparagus racemosus has been shown to increase the prolactin levels in female rats. Metoclopramide, a dopamine receptor antagonist with a poor penetration of the blood-brain barrier , is used in radiology and in patients with dyspepsia to increase the rate of emptying of the stomach, and also causes increase in milk secretion by increasing prolactin levels. hypothesised that Shatavari may be a mild dopamine antagonist, acting in a way similar to metoclopramide . Shatavari, sometimes wild asparagus Known as, is Primarily a reproductive tonic (both male and female), a demulcent for the digestive system, and a powerful adaptoge...