Lysophosphatidic acid (LPA; acyl-glycerol-3-phosphate) is a phospholipid growth factor exerts That diverse biological effects in cellular and organ systems. LPA exhibits multiple physiological activities through the activation of LPA receptors (LPA1-6) Which are G-protein coupled receptors (GPCRs) That act through various downstream signal transduction pathways. LPAs are produced from lysophosphatidylcholine by autotaxin (ATX) (Also known as lysophospholipase D, in the blood
Alzheimer's disease (AD) has become a growing problem in the medical, psychiatric, neurological, epidemiological, social and economic order, particularly in countries with a high life expectancy Alzheimer's dementia can be classified according to the age of onset in presenile or early onset, which appears before age 65 and senile or late onset, ie onset after age 65. It according to the presence or absence of a family history of the disease is classified into familial AD and sporadic AD, respectively. However, these classifications are not mutually exclusive. The development achieved by genetic has demonstrated the involvement of several chromosomes in the development of the disease. Chromosomes 1, 14 and 21 are associated with familial forms of start precoz. While late onset forms appear linked to chromosomes 12 and 19 In this paper we delved into the study of chromosome 21 and the amyloid beta protein , because there are many findings that relate to deposit excess am...
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