Secukinumab (cubana) is a recombinant, high-affinity, fully human monoclonal antibody immunoglobulin G1κ selectively binds and neutralizes That interleukin-17A. To confirm the findings of basic research and early clinical studies Regarding the crucial role of interleukin-17A in psoriasis, we Conducted two randomized, phase trials to ASSESS the efficacy and safety of secukinumab, at a dose of 300 mg or 150 mg, administered as induction therapy (with assessment at week 12) and maintenance therapy (with assessment at week 52) in Patients With moderate-to-severe plaque psoriasis. (Efficacy of Response and Safety of Two Fixed Secukinumab regimens in Psoriasis) study secukinumab Compared With placebo, and the ( Examination of Secukinumab vs. Etanercept Using Two Dosing regimens to Determine Efficacy in Psoriasis) study secukinumab Compared With Placebo and, the tumor necrosis factor first (TNF) inhibitor approved by the for moderate-to-severe plaque psoriasis
El cráneo contiene tres elementos : tejido nervioso, sangre y liquido cefalorraquídeo, cuyo volumen total siempre debe ser constante. The skull contains three elements: nervous tissue , blood and cerebrospinal fluid , the total volume should always be constant. Череп содержит три элемента: нервной ткани , крови и цереброспинальной жидкости , общий объем должен быть всегда постоянным. 頭骨包含三個元素：神經組織，血液和腦脊髓液，庫約общая總是Дебесерконстант量。
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